Oral Liquid Formulation Products

 What are Oral Liquid Formulation Products

Liquid dosage forms are prepared by dissolving active pharmaceutical ingredients in aqueous and non-aqueous solvents, suspending the API inappropriate media, or incorporating the drug ingredients in oil or water phases.

In addition to the active substance, additives are also required to produce liquid dosage forms. These added excipients include carriers, stabilizers, preservatives, suspending agents, emulsifiers, solubilizers, coloring agents, flavoring agents, etc. When developing liquid pharmaceutical dosage forms,  the properties of the active ingredient are considered first, as the main challenges in developing oral formulations and contract manufacturing services for liquid Dosage forms are (i) the stability of a drug in a solution, (ii) the solubility of a drug at the required level and (iii) acceptable taste. Therefore, the properties of the active pharmaceutical ingredients selected for oral administration can dictate the nature of the oral liquid formulations formed.

Types of liquid dosage forms: 

 

Oral Liquids:   Oral Liquids Orally administered liquid dosage forms in the form of pharmaceutical solutions, suspensions, and emulsions are taken orally for drug administration.

Parenteral Liquids:   Sterile liquid products are liquid dosage forms of therapeutics that are free of viable microorganisms. Sterile liquids are used as parenterally administered injectable solutions for subcutaneous, intramuscular, or intravenous administration of drugs. Liquid dosage forms offer certain advantages over other specialized finished dosage forms, such as  Increased patient compliance, faster absorption, and greater flexibility in dosing. In addition, oral liquid dosage forms are better than tablets or other oral solid dosage forms for patients who have difficulty swallowing. This makes it the preferred specialty dosage form for pediatric and geriatric patients. Liquids also absorb faster than oral solids in body fluids and offer dosage flexibility In addition, liquids are more palatable than oral solid dosage forms. These advantages that oral liquids offer make them an attractive dosage form for the oral administration of drugs.

Oral suspension:  In the development of formulations for use in oral dosage structures, a commonly used pharmaceutical liquid dosage structure is oral suspension. They can be characterized as assemblies containing finely divided drug particles that are to some extent consistently transported through a medium in which the drug has a basal solution level.

Oral liquid syrups: Oral liquid syrups are viscous answers that incorporate one or extra lively ingredients. The base includes big quantities of sugar together with sucrose or sorbitol, that can inhibit crystallization, alternate taste, base homes, and/or alter solubilization.

 Mouth Washes: Oral mouthwashes or gargles are answers designed to deal with infections and inflammations of the oral cavity. They aren't supposed to be swallowed.

Advantages of liquid dosage forms:

- It is Better for patients who have trouble swallowing

- Faster absorption than solids including oral solids

- More flexibility in dosing 

- Palatable 

- The best choice for geriatric and pediatric patients

How to differentiate solid Formulations

The main differences between solid cosmetics are in the type of matrix or base (lipophilic or hydrophilic), their consistency (loose powder vs. bars, sticks, or cakes), as well as their availability in bulk or pre-dosed units such as single-dose E. . Sachets, tablets, sheets, pods or granules. Solid is a state of matter in which the cohesive forces between the particles that make up the material are strong enough for the material to have a definite and stable shape and volume at rest. Water, with its primary function as a polar solvent in cosmetics, has the ability to impart liquid properties or aid in the development of a liquid crystalline state in a formulation. However, its absence does not automatically mean a solid formulation as with other non-aqueous ones, but polar solvents such as propanediol can be used. It is thus possible to produce products without water but with a polar base that can assume a solid or liquid state depending on the type of formulation.

Conclusion:  This study showed that oral liquid medicines are a suboptimal alternative to solid oral dosage forms in patients with dysphagia. To ensure optimal acceptance, prescribing physicians should also consider the presence of a taste masker in these oral fluids.